General Overview
1. What is pharma packaging?
2. Importance of packaging
3. Functions of packaging
4. Material characteristics Choosing the Appropriate Primary
Pack Suitable polymer/ Blister Packs Containers & Closures
What is packaging ?
Packaging is defined as the collection of different
components which surround the pharmaceutical product from the time of
production until its use.
Importance of packaging
Protect against all adverse external influences that can
alter the properties of the product.
• Protect against biological contamination.
• Protect against physical damage.
• Carry the correct
information and identification of the product.
• Tamper evident / Child resistance / Anti counterfeiting.
Functions of
packaging
- · Containment
- · Not to leak, nor allow diffusion and permeation
- · Strong enough to hold the contents during handling
- · Protection
- · Light
- · Moisture
- · Oxygen
- · Biological contamination
- · Mechanical damage
- · Counterfeiting
Material
characteristics
Additional qualities
required
· It must
preserve the physical properties of all dosage
·
Forms and protect them against damage or
breakage.
·
It must not alter the identity of the product.
·
It must preserve the characteristics properties
of the product to comply specifications.
·
It must protect product against undesirable or adulterating chemical, biological or physical entities. Don't miss this article:how to use triple laminated bags for pharma packaging.
Selection of
packaging material
- · Moisture barrier requirements
- · Light barrier requirements
- · Gas barrier requirements
- · Chemical properties
Choosing appropriate
primary pack
Desiccants have been utilized to control the exposure of
products to the ingress of moisture. Desiccants vary in their capacity and the
rate that they adsorb/absorb ingressed moisture. Silica gel & oxygen
absorber is very efficient at absorbing
moisture at high relative humidity, but comparatively poor at lower Relative
Humidity. Molecular sieve desiccants
- the opposite scenario prevails. As a consequence, more molecular sieve is required at higher relative humidity, and the
greater the handling precautions that are required during packaging operations.
Based on the calculated WVTR of known container components and the rate of
moisture adsorbed by desiccants, the amount of desiccant that would be required
to maintain a specified relative humidity over the product’s shelf-life can be
determined and used. Also Read: Best Guidelines for Pharma packaging using LDPE bags
TESTING AND
STABILITY
- · QC test - routine tests
- · Vary according to the type of material used
- · Visual inspection
- · Identification test
- · Dimensional test
- · Physical tests
- · Chemical tests
- · Microbiological tests
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